The chirality quantification is of great importance in structural biology, where the Accessories differences in proteins twisting can provide essentially different physiological effects.However, this aspect of the chirality is still poorly studied for helix-like supramolecular structures.In this work, a method for chirality quantification based on
Mesoangioblasts from Facioscapulohumeral Muscular Dystrophy Display in Vivo a Variable Myogenic Ability Predictable by their in Vitro Behavior
Facioscapulohumeral muscular dystrophy (FSHD) is the third most frequent inherited myopathy.We previously demonstrated that mesoangioblasts can be efficiently isolated from FSHD muscles, although their differentiation ability into skeletal muscle was variably WAND impaired.This correlates with overall disease severity and degree of histopathologic
Stereoselective Bioreduction to a Chiral Building Block on a Kilogram Scale
The highly stereoselective bioreduction of ethyl cyclohexanone-2-carboxylate (1) on a kilogram scale is described.Ethyl(1S,2S)-trans-2-hydroxycyclohexane carboxylate (2) was prepared in 56% yield with a diastereomeric ratio (dr) of 99:1 and an enantiomeric ratio (er) of Accessories 99.5:0.5 after rectification.The cell growth and the biotransformat